Melanotan I

Buy Melanotan 1 online from Research Chems Australia

Melanotan 1 is a synthetic peptide researched for its effects as a sunless tanning agent, shipped same business day from Melbourne with free express shipping on orders over $200.

What Is Melanotan 1?

Melanotan 1 is a synthetic peptide analogue of alpha-melanocyte-stimulating hormone, originally developed at the University of Arizona as a sunless tanning agent.

The pharmaceutical form of Melanotan 1, known as afamelanotide (brand name Scenesse), became the first FDA-approved melanocortin-based therapy in 2019, approved for erythropoietic protoporphyria (EPP). It also holds EMA and TGA approval, making it one of the few melanocortin peptides to complete the full regulatory pathway.

---

How Does Melanotan 1 Work?

Melanotan 1 primarily activates the melanocortin 1 receptor (MC1R) to stimulate melanin production:

Unlike Melanotan 2, which is a non-selective agonist across multiple melanocortin receptors (MC1, MC3, MC4, MC5), Melanotan 1 is more selective for MC1R, resulting in more targeted pigmentation effects with fewer off-target side effects.

---

Research Focus Areas

Melanotan 1 is being studied for its potential effects on:

• Skin pigmentation — stimulation of eumelanin synthesis and melanocyte proliferation
• Photoprotection — UV damage reduction through increased melanin density
• Erythropoietic protoporphyria — increased tolerance to light exposure in EPP patients
• Vitiligo — repigmentation of depigmented skin patches
• Actinic keratosis — prevention of UV-induced precancerous skin lesions
• Anti-inflammatory action — modulation of inflammatory cascades and fibrogenic gene expression
• Polymorphous light eruption — reduction in photosensitivity reactions

Clinical trials with afamelanotide demonstrated significantly increased pain-free sun exposure time in EPP patients, with common adverse effects limited to headache, nausea, and fatigue.