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- The RCA Team
Essential coenzyme for cellular energy and longevity research.
SKU: NAD-500MG
NAD+ is a vitamin B3 coenzyme present in every living cell, crucial for energy metabolism and DNA repair, shipped same business day from Melbourne with free express shipping on orders over $200.
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every living cell, representing the biologically active, oxidized form of vitamin B3. NAD+ has emerged as one of the most critical molecules in cellular biology. Central to energy metabolism, DNA repair, epigenetic regulation, and cellular stress responses.
NAD+ serves two fundamental roles: as an essential electron carrier in metabolic redox reactions, and as a consumed substrate for key enzyme families that link cellular energy status to DNA repair, chromatin structure, immune signaling, and aging processes. Intracellular NAD+ levels decline significantly with age, dropping approximately 50% between age 20 and 60.
NAD+ is central to multiple hallmarks of aging:
| Mechanism | Primary Effects | Aging Relevance |
|---|---|---|
| Sirtuin Activation (SIRT1–7) | Protein deacetylation, gene expression regulation | Sirtuin activity declines as NAD+ drops with age |
| PARP-Mediated DNA Repair | Single-strand break repair, genomic stability | PARP activity increases with age, consuming more NAD+ |
| CD38 Regulation | NAD+ glycohydrolase activity, immune signaling | CD38 expression increases with age, accelerating NAD+ breakdown |
| Redox Metabolism | Electron transport chain, ATP generation | Mitochondrial dysfunction is a hallmark of cellular aging |
This age-related NAD+ deficit creates a depletion cycle. As PARP and CD38 activity increase with age, they consume more NAD+, further reducing sirtuin function and accelerating metabolic decline.
NAD+ is being studied for its potential effects on:
Multiple randomized clinical trials using NAD+ precursors have demonstrated consistent blood NAD+ elevation of 50–100%+ above baseline, with promising results across neurodegeneration, inflammation, and metabolic parameters.
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Common questions about NAD+
FOR RESEARCH USE ONLY. NOT FOR HUMAN CONSUMPTION. This product is intended for laboratory and research purposes only. Not for human or animal consumption.
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