CJC-1295 No DAC

The Modified GHRH Analog

CJC-1295 (No DAC), also known as Modified GRF (1-29) or Mod GRF (1-29), is a synthetic 29-amino acid analog of growth hormone-releasing hormone (GHRH). This peptide incorporates four amino acid substitutions that enhance stability and resistance to enzymatic degradation while preserving the natural pulsatile pattern of growth hormone release.

Unlike CJC-1295 with DAC, which provides sustained GH elevation over days, the No DAC version maintains a shorter half-life (~30 minutes), better mimicking the body's natural GHRH signaling.

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Why Pulsatile Release Matters

CJC-1295 (No DAC) preserves physiological GH secretion patterns:

Parameter	CJC-1295 with DAC	CJC-1295 No DAC
Half-life	6-8 days	~30 minutes
GH Pattern	Sustained elevation	Pulsatile release
Dosing Frequency	Weekly	Multiple daily
Physiological Mimicry	Low	High

Pulsatile GH release is considered important for many of the hormone's physiological effects while minimizing side effects.

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Research Focus Areas

CJC-1295 (No DAC) is being studied for its potential effects on:

• Growth hormone stimulation — enhanced pulsatile GH release
• IGF-1 elevation — downstream growth factor production
• Body composition — lean mass increase and fat reduction
• Sleep quality — GHRH-mediated sleep enhancement
• Recovery and repair — tissue regeneration support
• Anti-aging — GH axis optimization
• Metabolic function — improved substrate utilization

Often studied in combination with GHRPs like Ipamorelin for synergistic effects.

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Clinical Development Context

• Developer: ConjuChem Biotechnologies (DAC version)
• Phase: Phase II completed (DAC version); No DAC version is research-only
• Published data: Human studies on GH/IGF-1 elevation
• Regulatory status: Not FDA approved; WADA prohibited substance

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Technical Specifications

• Synonyms: Modified GRF (1-29), Mod GRF (1-29), Tetrasubstituted GRF (1-29)
• Class: GHRH analog / Growth hormone secretagogue
• Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂
• Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
• Molecular Weight: ~3,367.9 g/mol (without DAC)
• Form: Sterile lyophilized powder
• Half-life: ~30 minutes

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Storage & Handling

• Lyophilized: Store at -20°C
• Reconstituted: Store at 2–8°C
• Protect from light and moisture
• Avoid repeated freeze-thaw cycles

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