BPC-157

The Body Protection Compound

BPC-157 (Body Protection Compound-157) is a synthetic 15-amino acid peptide derived from a protein found in human gastric juice. First isolated and characterized in the early 1990s, this pentadecapeptide has demonstrated remarkable stability and a broad spectrum of cytoprotective and regenerative effects across numerous preclinical models.

With over 100 peer-reviewed publications documenting its effects, BPC-157 has become one of the most extensively studied peptides in regenerative medicine research, though it remains without regulatory approval for human therapeutic use.

---

Why Gastric Origin Matters

BPC-157's derivation from gastric juice contributes to its unique properties:

Property	Significance	Research Implication
Gastric Stability	Survives >24 hours in gastric juice	Oral bioavailability potential
No Sequence Homology	Unique among known peptides	Novel mechanism of action
Cytoprotective	Protects multiple tissue types	Broad therapeutic potential
Pleiotropic Effects	Activates multiple pathways	Systemic healing effects

The peptide's remarkable stability in the harsh gastric environment and its ability to affect multiple organ systems distinguish it from other regenerative peptides.

---

Research Focus Areas

BPC-157 is being studied for its potential effects on:

• Musculoskeletal healing — tendon, ligament, muscle, and bone repair
• Gastrointestinal protection — mucosal integrity and gut barrier function
• Angiogenesis — new blood vessel formation via VEGFR2 pathway activation
• Neuroprotection — dopaminergic and serotonergic system modulation
• Anti-inflammatory action — modulation of inflammatory cascades
• Wound healing — accelerated tissue repair and reduced scarring
• Growth hormone receptor expression — enhanced tissue regeneration capacity

Preclinical studies demonstrate effects across skin, muscle, bone, ligament, tendon, and gastrointestinal tissues.

---

Clinical Development Context

• Origin: Isolated from human gastric juice
• Phase: Preclinical (limited human data)
• Published data: >100 peer-reviewed publications
• Human studies: One retrospective study (chronic knee pain, n=12)
• Regulatory status: Not FDA approved; previously on WADA prohibited list

---

Technical Specifications

• Synonyms: BPC-15, PL-10, PLD-116, PL14736, Bepecin
• Class: Gastric pentadecapeptide / Cytoprotective peptide
• Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
• Molecular Formula: C₆₂H₉₈N₁₆O₂₂
• Molecular Weight: 1,419.53 g/mol
• Form: Sterile lyophilized powder
• Half-life: <30 minutes (IV/IM administration)

---

Storage & Handling

• Lyophilized: Store at -20°C
• Reconstituted: Store at 2–8°C
• Protect from light and moisture
• Avoid repeated freeze-thaw cycles

---